Kinases are a major target for many drugs, including many anti-cancer therapies. They play a set of very important roles in molecular biology, and many diseases are affected by them in some way. The various categories of Kinases and their relation to diseases have been compiled by researchers. The molecular basis of their role in diseases is known for quite a few of them, and continues to grow-- this knowledge is sometimes referred to as the Kinome.
The following information on Kinases was obtained from Fabian et al. and Cell Signaling (http://www.cellsignal.com/reference/kinase_disease.html), and the tables were converted directly into RDF (source), the Semantic Web format, using Babel. The RDF is rendered as an interactive web page using Exhibit. The various row colors represent different Kinase Groups or Families.
Feel free to send me any questions or suggestions you may have on this data viewer.
How to use the Exhibit View: Click on the table headers to sort a column in descending or ascending order. The three facet views on the right represent the different types for the Kinase Groups, Assays, and Compound Categories. By selecting any combination of their listed types, the view will display only those filtered entries. The numbers left of each type indicate how many visible entries match each type. Clicking on Compound links offers the user to do an automatic search at the BindingDB, where the structure can be rendered using ChemAxon's Marvin viewer. A scatter-plot of Kd vs IC50 can be viewed by clicking on the above menus; current views are underlined in red. You can shift to the Kinase-Disease View by clicking on the link below. A snap-shot of any current data view can be "copied" as RDF by clicking on the scissor icon above.
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